Transgenic Expression of Syndecan-1 Uncovers a Physiological Control of Feeding Behavior by Syndecan-3

نویسندگان

  • Ofer Reizes
  • John Lincecum
  • Zihua Wang
  • Olga Goldberger
  • Li Huang
  • Marko Kaksonen
  • Rexford Ahima
  • Michael T. Hinkes
  • Gregory S. Barsh
  • Heikki Rauvala
  • Merton Bernfield
چکیده

Transgenic expression in the hypothalamus of syndecan-1, a cell surface heparan sulfate proteoglycan (HSPG) and modulator of ligand-receptor encounters, produces mice with hyperphagia and maturity-onset obesity resembling mice with reduced action of alpha melanocyte stimulating hormone (alphaMSH). Via their HS chains, syndecans potentiate the action of agouti-related protein and agouti signaling protein, endogenous inhibitors of alphaMSH. In wild-type mice, syndecan-3, the predominantly neural syndecan, is expressed in hypothalamic regions that control energy balance. Food deprivation increases hypothalamic syndecan-3 levels several-fold. Syndecan-3 null mice, otherwise apparently normal, respond to food deprivation with markedly reduced reflex hyperphagia. We propose that oscillation of hypothalamic syndecan-3 levels physiologically modulates feeding behavior.

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عنوان ژورنال:
  • Cell

دوره 106  شماره 

صفحات  -

تاریخ انتشار 2001